Endocrine Abstracts

Low-carbohydrate/high fat diets (LC-HFD) effectively induce body weight loss in both animals and humans; however, in rats this is paralleled by increased visceral adiposity contributing to impaired glucose tolerance. Estrogen inhibits adipose tissue accumulation, with estrogen deficient female animals displaying increased body weight and visceral adiposity with reduced insulin sensitivity, which can be reversed with estrogen replacement. Consistent with the effects seen in fem...

Moderate, ‘Atkin’s-style’ low-carbohydrate/high fat diets (LC-HFD) are claimed to induce weight loss in overweight subjects and to ameliorate glucose metabolism, whereas extreme ketogenic LC-HFD are used to treat neurological disorders like pediatric epilepsy. To investigate the effects of both types of LC-HFD on glucose and insulin metabolism independent of the energetic intake, we pair-fed male Wistar rats isoenergetic of standard rodent chow (CH) or one of tw...

Ageing is associated with sarcopenia, osteoporosis and an increased risk of falling, which together contribute to increased fracture risk. There are few data describing the associations between functional measures of muscle and bone during ageing. Therefore, the aim of this study was to examine in ageing men associations between measures of lower-limb muscle strength and age and then to investigate the relationships with tibial bone outcomes.Men (n</...

Ketogenic low-carbohydrate/high fat diets (LC-HFD) induce weight loss in both animals and humans. However, a number of unwanted side effects with these diets have been reported. We have previously shown in male rats that LC-HFDs negatively affect bone growth and bone mineral density, possibly due to macronutrient-induced impairments of the GH/IGF-system. Given the importance of dietary macronutrients in the regulation of bone density in male rats, in this study we investigated...